• Sign In to gain access to subscriptions and/or My Tools.
Impact Factor:0.456 | Ranking:Medical Informatics 24 out of 24 | Pharmacology & Pharmacy 242 out of 254
Source:2014 Journal Citation Reports® (Thomson Reuters, 2015)

Drug-Induced Autoimmunity and Autoimmune Disease

  1. Norman Talal, MD1
  2. Howard Dang, PhD1
  1. 1 University of Texas Health Science Center at San Antonio, Department of Medicine, Divsion of Clinical Immunology, San Antonio, Texas
  1. University of Texas Health Science Center at San Antonio, Department of Medicine, Divsion of Clinical Immunology, 7703 Floyd Curl Drive, San Antonio, TX 78284-7874

Abstract

Autoimmunity and autoimmune disease are two different things. Autoimmunity can be physiologic (natural autoantibodies), is a normal consequence of aging, and is potentially reversible (as in drug-induced autoimmunity which disappears when the offending drug is eliminated). Autoimmune disease is a pathologic attack by a self-destructive hostile immune system for reasons unknown, although genetic, possibly viral, hormonal, and environmental factors are all involved. Autoimmune disease has been likened to a civil war in which “friendly fire” does much of the damage.

A new development in autoimmunity is its relationship to apoptosis or Programmed Cell Death (PCD). Abnormalities of PCD occur in autoimmune mice and in autoimmune patients. Autoantibodies may be produced in response to DNA and nucleoprotein fragments that arise during PCD.

Over 70 drugs are capable of inducing a lupus-like syndrome with antinuclear factors, arthritis, skin rashes, and pleurisy. Autoimmunity and autoimmune disease in these patients represents a form of immunotoxicity, perhaps an immune deviation related to cytokine imbalance and/or abnormal PCD in which the autoimmune potential that exists in all of us attains a level of serologic and clinical expression.

| Table of Contents